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Evaluation of PRL-3 expression, and its correlation with angiogenesis and invasion in hepatocellular carcinoma
International Journal of Molecular Medicine
Protein phosphatase of regenerating liver 3 (PRL-3) is a metastasis-associated phosphatase. Studies have shown that its overexpression increases cell motility and invasiveness. In this study, we aimed to investigate the expression of PRL-3 in hepatocellular carcinoma (HCC) tumor tissues and determine its correlations with matrix metalloproteinases (MMP-2, MMP-9) and E-cadherin in HCC. Paired cancerous and noncancerous tissues were freshly collected from 42 primary HCC patients. PRL-3 expressiondoi:10.3892/ijmm_00000007 fatcat:zxwu3vjy3vg2vmw7kkaafkqrwa