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A rational approach of early humane endpoint determination in a murine model for cholestasis
ALTEX: Alternatives to Animal Experimentation
Reduction of animal suffering during in vivo experiments is usually ensured by continuously monitoring the health status using a score sheet and by applying humane endpoints. However, most studies do not evaluate the plausibility of score sheets and do not attempt to reduce the suffering of animals by determining earlier and, therefore, more humane endpoints. The present study uses data from BALB/cANCrl mice after bile duct ligation to retrospectively analyze which score sheet criteria aredoi:10.14573/altex.1909111 pmid:31825086 fatcat:l5vazuauz5a4dnvon2rijoumj4