Uremic patients have two opposite features in hemostatic status, that is, bleeding and thrombophilic ten dency. Platelet functions for normal hemostasis are impaired, possibly contributing to the bleeding tendency in uremic patients. In contrast, platelet hyperaggregability and hypercoagulability that are commonly observed in uremic patients may be associated with their high incidence of thrombotic diseases. Recent studies suggested that platelet microparticles (PMPs) which are small vesicles

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... th procoagulant activity released from the activated platelets might be relevant to thrombogenesis.