Tinbergen's challenge for the neuroscience of behavior

Donald Pfaff, Inna Tabansky, Wulf Haubensak
2019 Proceedings of the National Academy of Sciences of the United States of America  
Nobel laureate Nikolaas Tinbergen provided clear criteria for declaring a neuroscience problem solved, criteria which despite the passage of more than 50 years and vastly expanded neuroscience tool kits remain applicable today. Tinbergen said for neuroscientists to claim that a behavior is understood, they must correspondingly understand its (i) development and its (ii) mechanisms and its (iii) function and its (iv) evolution. Now, all four of these domains represent hotbeds of current
more » ... tal work, each using arrays of new techniques which overlap only partly. Thus, as new methodologies come online, from single-nerve-cell RNA sequencing, for example, to smart FISH, large-scale calcium imaging from cortex and deep brain structures, computational ethology, and so on, one person, however smart, cannot master everything. Our response to the likely "fracturing" of neuroscience recognizes the value of ever larger consortia. This response suggests new kinds of problems for (i) funding and (ii) the fair distribution of credit, especially for younger scientists.
doi:10.1073/pnas.1903589116 pmid:31036636 pmcid:PMC6525541 fatcat:l4fujl6io5bixe2q76noajb6jm