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In the 1950s Francis Crick formulated the Central Dogma of molecular biology, which states (in effect) that DNA makes RNA makes protein makes us. By 1970, however, biologists knew that the vast majority of our genome does not encode proteins, and the non-protein-coding fraction became known as " junk DNA." Yet data from recent genome projects show that most nuclear DNA is transcribed into RNAs, many of which perform important functions in cells and tissues. Like protein-coding DNA,doi:10.1142/9789814508728_0009 fatcat:cqojl25q7redvdbjqx3bwgmfya