Neerkovai is a sidha medicine for the treatment of Sinusitis. Nine plant components and borax dehydrate are the constituents of this medicine. The present work embarks upon the antibacterial, antioxidant and GC MS analysis of this medicine. It was found that Neerkovai works as a mild antibacterial against pathogens like Staphylococcus aureus, Streptococcus pyogenes, Pseudomonas aeruginosa and Klebsiella pneumoniae at higher doses of 12.5, 25, 37.5 and 50 mg/ml of distilled water solutions. The

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... ntioxidant study revealed that in all the three assays, namely DPPH, FRAP and Hydrogen peroxide scavenging, Neerkovai gave highest activity in Ethanol solution as compared to methanol and water solutions. The GC MS analysis indicated the presence of important medicinal bio molecules, such as Isoborneol, Eugenol, Ar-tumerone, Desmethylnomifensine, Piperine, Isoquinoline, 1,2,3,4-tetrahydro-8-amino-2-methyl-4-phenyl, Dehydroabietic acid, Abietic acid,-Pimaric acid, Oleic Acid, n-Hexadecanoic acid, Ar-tumerone, Phenol, 2,4-bis(1,1-dimethylethyl)-, Geranyl-p-cymene. The biological activity of some of the compounds which were present in high quantities such as, Phenol, 2-methoxy-4-(2-propenyl)-, acetate, Benzenepropanoic acid, "-dimethyl-, methyl ester, 6-(p-Tolyl)-2-methyl-2-heptenol, trans-, Curlone, Phenol, 2-methyl-5-(1,2,2-trimethylcyclopentyl)-, (S)-is hitherto not known and further work M. R. K Rao* et al.