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Motivation: Post-sequencing DNA analysis typically consists of read mapping followed by variant calling. Especially for whole genome sequencing, this computational step is very time-consuming, even when using multithreading on a multi-core machine. Results: We present Halvade, a framework that enables sequencing pipelines to be executed in parallel on a multi-node and/or multi-core compute infrastructure in a highly efficient manner. As an example, a DNA sequencing analysis pipeline for variantdoi:10.1093/bioinformatics/btv179 pmid:25819078 pmcid:PMC4514927 fatcat:2nmppry6nnfqrjhdljpukm5r3a