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A systematic analysis of interactions between environmental risk factors and genetic variation in susceptibility to colorectal cancer
2020
Cancer Epidemiology, Biomarkers and Prevention
◥ Background: The underlying etiology of colorectal cancer includes both genetic variation and environmental exposures. The main aim of this study was to search for interaction effects between well-established environmental risk factors and published common genetic variants exerting main effects on colorectal cancer risk. Methods: We used a two-phase approach: (i) discovery phase (2,652 incident colorectal cancer cases and 10,608 controls from UK Biobank) and (ii) validation phase (1,656 cases
doi:10.1158/1055-9965.epi-19-1328
fatcat:wnyhyjvk3vbizbdxhsf727lvfq