新しいヒスタミンH2受容体しゃ断薬Ranitidineの臨床薬理学的検討
The Clinical Pharmacology of Ranitidine, a New Histamine H2-Receptor Blocking Agent

Akio EBIHARA, Taichi OKA, Kazuji TAWARA, Kyoichi OHASHI, Kazuoki KONDO, Takeshi WATABE, Masahiko OKIYAMA, Kunihisa MANBO
1982 Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics  
The pharmacokinetics of ranitidine, a new H2-receptor blocking agent, and its effects on tetragastrin-induced gastric acid serection were studied in five healthy volunteers. The ranitidine concentrations in plasma and urine were determined by HPLC. After single oral administration of ranitidine (100 mg or 150 mg tablet), the peak plasma concentration of the drug was attained in 2-2.5 hrs and the elimination half-life was 2-2.5 hrs when they were obtained from the 24-hr plasma concentration-time
more » ... concentration-time curve.
doi:10.3999/jscpt.13.265 fatcat:s6h6h455c5dnhe6ohfjidyjnae