32nd International Symposium on the Autonomic Nervous System

2021 Clinical Autonomic Research  
Parkinson's disease with orthostatic hypotension (PD ? OH) can be difficult to distinguish clinically from the parkinsonian form of multiple system atrophy (MSA-P). Previous studies examined cardiac sympathetic neuroimaging to differentiate PD from MSA but without focusing specifically on PD ? OH versus MSA-P, which often is the relevant differential diagnostic issue. We aimed to investigate the utility of cardiac sympathetic neuroimaging by 18F-dopamine positron emission tomographic (PET)
more » ... ing for separating PD ? OH from MSA-P.' Methods: Cardiac 18F-dopamine PET data were analyzed from 50 PD ? OH and 68 MSA-P patients evaluated at the NIH Clinical Center from 1990 to 2020. Noradrenergic deficiency was defined by interventricular septal 18F-dopamine-derived radioactivity \ 6000 nCi-kg/cc-mCi in the 50 frame with mid-point 80 after initiation of 30 tracer injection. The subjects participated in protocols approved by the Institutional Review Board of the NINDS after having given written informed consent. Results: 18F-Dopamine PET separated the PD ? OH from the MSA-P group with a sensitivity of 92% and specificity of 96%. Conclusion: Cardiac 18F-dopamine PET scanning efficiently distinguishes PD ? OH from MSA-P.
doi:10.1007/s10286-021-00822-5 pmid:34564798 pmcid:PMC8475849 fatcat:oa7c2r6k2neabeh7tsgmt42ar4