High-dose versus Low-dose 5-Fluorouracil and Cisplatin Based Hepatic Arterial Infusion Chemotherapy for Advanced Hepatocellular Carcinoma

Chae-June Lim, Ji-Yun Hong, Yang-Seok Ko, Min-Woo Chung, Chung-Hwan Jun, Sung-Kyu Choi, Sung-Bum Cho
2019 Journal of Liver Cancer  
Backgrounds/Aims: Hepatic arterial infusion chemotherapy (HAIC) has been reported as an effective treatment for advanced hepatocellular carcinoma. The aim of this study is to compare the effect and safety between a high-dose regimen (750 mg/m 2 5-fluorouracil [FU] and 25 mg/m 2 cisplatin on day 1-4) and a low-dose regimen (500 mg/m 2 5-FU on day 1-3 with 60 mg/m 2 cisplatin on day 2). Methods: A total of 48 patients undergoing HAIC were retrospectively analyzed. Thirty-two patients were treated
more » ... with the high-dose and 16 patients with the low-dose regimen.
doi:10.17998/jlc.19.1.38 fatcat:tne7e6o5mfhy5hrtrf5o22iwta