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Systemic enzyme therapy (SET), developed by M. Wolf and K. Ransberger in 1954, is a method of treatment and prevention of diseases with the help of specially selected combination of hydrolytic enzymes of vegetable or animal origin (biological catalysts) that affect key physiological and pathophysiological processes in body. Systemic effects of exogenous enzymes provided direct or indirect effect on the hydrolase activity of the major organs and body systems through the modulation of their owndoi:10.20514/2226-6704-2012-0-1-15-19 doaj:c8653dc6426846409b7e675005785d46 fatcat:z6klluz2drehnaryb36lntdypy