Risk Analysis of Severe Thrombocytopenia in Nasopharyngeal Carcinoma During Concurrent Radio-Chemotherapy [post]

Jiasheng Xu, Quanli Wu, Luoyong Tang, Anwen Liu, Long Huang
2021 unpublished
Objective:To explore the risk factors and predictive indexes of severe thrombocytopenia during concurrent radio-chemotherapy of nasopharyngeal carcinoma. Methods: Retrospective analysis were performed from the hospitalized patients with nasopharyngeal carcinoma from August 2014 to July 2017 and completed induction chemotherapy and concurrent radio-chemotherapy.Patients were divided into observation and control group according to the lowest platelet count during concurrent chemotherapy. The
more » ... motherapy. The general information and laboratory examinations were recorded and analyzed by univariate analysis, multivariate regression analysis and ROC curve analysis. Results: Take the factors, including Age, PLT, IBIL, APTT at first visit, WBC, RBC, HGB, PLT, NEUT, APTT,IBIL, FFA, Crea,Urea before radio-chemotherapy, which are significant in univariate analysis into multivariate regression analysis. It turned out that RBC(OR=10.060, 95%CI2.679-37.777, P=0.001),PLT(OR= 1.020, 95%CI1.006-1.034, P=0.005) and IBIL(OR=0.710,95%CI 0.561-0.898, P= 0.004) are independent predictors of severe TP in NPC. ROC analysis showed that the AUC of RBC, IBIL, PLT, AGE is 0.746(P< 0.001), 0.735(P<0.001), 0.702(P=0.001), 0.734(P<0.001). New variables called joint predictor was calculated by regression equation (Y=2.309*RBC-0.343*IBIL+0.02*PLT-10.007), the AUC of which is 0.870(P<0.001), best truncation value is>5.87 mmol/L. Conclusions: Lower RBC, PLT, higher IBIL before concurrent radio-chemotherapy are the independent risk factors causing severe TP during concurrent radio-chemotherapy of NPC. The RBC, PLT, IBIL before concurrent radio-chemotherapy and joint predictor have a good predictive value to evaluate the risk of severe TP during concurrent radio-chemotherapy of NPC.
doi:10.21203/rs.3.rs-386898/v1 fatcat:rgxnpdtpmrbyras42upefjgvpe