A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2021; you can also visit the original URL.
The file type is application/pdf
.
Computational quantification of global effects induced by mutations and drugs in signaling networks of colorectal cancer cells
[article]
2020
bioRxiv
pre-print
Colorectal cancer (CRC) is one of the most deadly and commonly diagnosed tumors worldwide. Several genes are involved in its development and progression. The most frequent mutations concern APC, KRAS, SMAD4, and TP53 genes, suggesting that CRC relies on the alteration of different pathways. However, with classic molecular approaches, it is not easy to simultaneously analyze the interconnections between these pathways. For this reason, we propose a computational model based on a huge chemical
doi:10.1101/2020.12.30.424842
fatcat:ui4ddn7hazgfdalzpbioznjvd4