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Pneumonia associated with mechanical ventilation (VAP) is one of the important causes of nosocomial infections in pediatric intensive care units (PICU). VAP is the leading cause of morbidity and mortality in PICUs. Aim: To assess the compliance to ventilator bundle components: elevation of the head of bed >30, sedation interruption, spontaneous breathing trial, peptic ulcer prophylaxis and its effect on the prevention of VAP. Subjects and Methods: A case control study at PICU of Abo EL Reish Eldoi:10.9790/5728-0621115 fatcat:cnrduscbyfbspmpxcnomglvs5y