Association between serum copper levels and cervical cancer risk: a meta-analysis

Min Zhang, Min Shi, Yan Zhao
2018 Bioscience Reports  
23 Whether serum copper levels were higher in patients with cervical cancer than that 24 in controls was controversial. Hence, we conducted this study to explore the 25 relationship between serum copper levels and cervical cancer. We searched PubMed, 26 WanFang and China National Knowledge Internet (CNKI) for relevant studies before 27 November 30th, 2017. Standardized mean difference (SMD) and 95% confidence 28 interval (CI) were used to combine results across studies using the random-effect
more » ... the random-effect 29 model. A total of 14 publications involving 747 patients with cervical cancer and 30 1014 controls were eligible through inclusion criteria. In comparison with controls, 31 serum copper levels were significant higher in patients with cervical cancer [summary 32 SMD = 1.35, 95%CI= 0.10 -2.59], with significant heterogeneity (I 2 = 98.8%, P< 33 0.001) was found. Significant association was also found among Asian populations 34 [summary SMD = 1.39, 95%CI= 0.06 -2.71]. The association was positive in 35 subgroup analysis of population-based case-control studies [summary SMD = 1.64, 36 95%CI= 0.02 -3.34], but not in hospital-based case-control studies. Through a 37 sensitivity analysis, we did not identify any single study to strongly influence the 38 results of our serum copper levels and cervical cancer risk. No publication bias was 39 found in our analysis. In conclusions, our study provided significant evidence of 40 higher serum copper levels in patients with cervical cancer than in controls, 41 suggesting that serum copper exposure was a risk factor on cervical cancer. 42 43
doi:10.1042/bsr20180161 pmid:29519960 fatcat:pj2mbes4zbhn5mcaevbf4g4oma