Type 2 diabetes mellitus is a metabolic disorder characterized by insulin resistance [affecting carbohydrate, lipid and protein metabolism]. Glycation of proteins, including hemoglobin and albumin have been implicated in comp diabetes. The aim of the present study was to evaluate the association between variations in the levels of albumin and total proteins with glycated hemoglobin [HbA1c]. Present study involved 408 participants who visited Owaisi Hospital and Research Center, Hyderabad from

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... vember 2015 to June 2017. 204 were freshly detected diabetic patients and 204, age and sex matched healthy controls. Fasting blood glucose levels, HbA1c, plasma total proteins and plasma albumin were estimated. The objective diagnosed cases of Type 2 Diabetes Mellitus. HbA1c levels increased (p<0.001) from 4.90 ± 0.53 in controls to 9.02 ± 2.06 in cases, plasma albumin levels were decreased (P<0. plasma total protein levels were increased from 6.8±0.81 in controls to 7.31±0.93 [p< 0.0013*] in cases. Globulin levels increased (P<0.50) from 1. 68 ± 0.29 in controls to 1.74 ± 0.57 in cases. 0.43 in controls to 1.84± 0.36 in cases. Glycation accelerates albumin degradation via increasing catabolic rate and decreasing protein half-life, and competes with other proteins for glycation. Our study sho between HbA1c and serum albumin. Freshly detected diabetic patients were associated with increased total proteins and decreased A/G ratio. We observed in our study that albumin levels may be associated inversely with HbA1c values results may lead us to study the ways in which glucose and proteins may interact in a newer approach and could aid in understanding hyperglycemia and its estimation.