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Adaptive evolution of ASPM, a major determinant of cerebral cortical size in humans
2004
Human Molecular Genetics
A prominent trend in the evolution of humans is the progressive enlargement of the cerebral cortex. The ASPM (Abnormal spindle-like microcephaly associated ) gene has the potential to play a role in this evolutionary process, because mutations in this gene cause severe reductions in the cerebral cortical size of affected humans. Here, we show that the evolution of ASPM is significantly accelerated in great apes, especially along the ape lineages leading to humans. Additionally, the lineage from
doi:10.1093/hmg/ddh055
pmid:14722158
fatcat:vn7xk75h3nc7lezbvvilyvpm3q