The uplift capacity factor of cylindrical suction caisson in anisotropic and inhomogeneous clays considering the adhesion factor at the interface is investigated in this paper. The finite element limit analysis based on lower bound and upper bound analyses is used for analyzing purposes. The anisotropic undrained shear model is employed to describe the anisotropic and inhomogeneous clay. The impact of these dimensionless parameters on the ratio of inhomogeneity or strength gradient ratio, the

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... hesion factor, the ratio of depth over diameter, and the ratio of anisotropic undrained shear strengths on the uplift resistance and the collapse mechanisms of suction caisson foundations are determined. The multivariate adaptive regression splines technique is employed to access the sensitivity of all considered dimensionless parameters on the uplift capacity factor and to propose an empirical design equation as an effective tool for predicting the uplift capacity factor. The results presented in this paper can be guidance for the preliminary design of suction caissons in anisotropic and non-homogeneous clays that are useful for engineering practitioners.