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Naa10p promotes metastasis by stabilizing matrix metalloproteinase-2 protein in human osteosarcomas
N-α-Acetyltransferase 10 protein (Naa10p) mediates N-terminal acetylation of nascent proteins. Oncogenic or tumor suppressive roles of Naa10p were reported in cancers. Here, we report an oncogenic role of Naa10p in promoting metastasis of osteosarcomas. Higher NAA10 transcripts were observed in metastatic osteosarcoma tissues compared to non-metastatic tissues and were also correlated with a worse prognosis of patients. Knockdown and overexpression of Naa10p in osteosarcoma cells respectivelydoi:10.1101/243592 fatcat:fagsnrhlmrcfnp6y3xil54fpra