A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2022; you can also visit the original URL.
The file type is application/pdf
.
Evaluating statistical approaches to define clonal origin of tumours using bulk DNA sequencing: context is everything
2022
Genome Biology
AbstractClonal analysis of tumour sequencing data enables the evaluation of the relationship of histologically distinct synchronous lesions, such as co-existing benign areas, and temporally distinct tumours, such as primary-recurrence comparisons. In this review, we summarise statistical approaches that are commonly employed to define tumour clonal relatedness using data from bulk DNA technologies. We discuss approaches using total copy number, allele-specific copy number and mutation data, and
doi:10.1186/s13059-022-02600-6
pmid:35109903
pmcid:PMC8809045
fatcat:uj6saf43ifezjpjhn6mtp5pw2y