Different mechanisms account for the relative resistance of KG-1 and HL-60 cell lines to retrovirus infection

S J Collins
1988 Journal of Virology  
I infected three different human leukemic cell lines (K562, KG-1, and HL-60) with an amphotropic retrovirus vector (designated PA317/N2) which confers G418 resistance and contains the Moloney murine leukemia virus long terminal repeat. Compared with K562 cells, both KG-1 and HL-60 cells were relatively resistant to infection with this retrovirus vector. In HL-60 cells, this resistance appeared to result from diminished viral DNA synthesis, while in KG-1 cells there was a block to the genomic
more » ... k to the genomic integration of the viral DNA.
doi:10.1128/jvi.62.11.4346-4348.1988 fatcat:7n34z64x3jbh5cyfv5qtu5glju