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Kappa B site-dependent induction of gene expression by diverse inducers of nuclear factor kappa B requires Raf-1
The transcription factor nuclear factor kappa B (NF-kappa B) is sequestered in the cytoplasm of most cell types where it is complexed with its inhibitor (I kappa B). A large variety of agents, including growth factors, the tumor promoter phorbol 12-myristate 13-acetate, and the cytokine tumor necrosis factor alpha, initiate signal transduction pathways that converge upon the NF-kappa B-I kappa B complex, resulting in the dissociation of I kappa B and the translocation of NF-kappa B to thedoi:10.17615/xavn-cv19 fatcat:btillbmbm5amdauiyznsra3ldi