Human Journals Research Article February
Background-The World Health Organization recommends promoting traditional alternative herbal therapies in poor countries because modern drugs are out of reach for many populations. Objective-This study aimed at assessing antidiabetic potentials and survival function in alloxan-induced diabetic guinea-pigs treated during 28 days with Harungana madagascariensis Lama ex. Poir, Physalis peruviana (L.), Solanum americanum, and Tithonia diversifolia (Hem) A. Cray leaf-extracts. Methods-Animals were
... hods-Animals were divided in 3 groups: negative control untreated group, reference group treated with glibenclamide 0.25mg/kg BW and test groups treated with plant extracts 200mg/kg BW. Blood samples were collected and glucose levels assayed at Day1, Day3, Day5, Day7, Day14, Day21 and Day28. Mean percentages of change (MPCs) in glucose level from Day1 baseline were calculated. Kaplan-Meier survival test was applied to compare time-to-death occurrence during the 28 days of treatment. Results-All plants reduced glucose levels significantly, but comparative MPCs between groups from Day7 to Day21 were significantly different (p<0.05). Kaplan-Meier Survival functions showed that all 6/6 animals in control group died within 10 days (censored=0%) while 1/6 death occurred in reference group (censored=83.3%); 2/3 animals died in Solanum group (censored=33.3%); 1/3 animal died in Tithonia group (censored=66.7%); 0/3 or no death occurred during the time of observation in Harungana and Physalis groups (censored=100%). Conclusion-All four studied plants showed potential antidiabetic activity consistent with studies by others, but differed in their capacity to prevent death. This can be in part related to the efficacy and toxicity of each plant components. Extensive study is needed to fix appropriate medications regimens.