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Development of directly compressible metformin hydrochloride by the spray-drying technique Metformin hydrochloride exhibits poor compressibility during compaction, often resulting in weak and unacceptable tablets with a high tendency to cap. The purpose of this study was to develop directly compressible metformin hydrochloride by the spray-drying technique in the presence of polymer. Metformin hydrochloride was dissolved in solutions containing a polymer, namely polyvinylpyrrolidone (PVP K30),doi:10.2478/v10007-010-0016-9 pmid:21134853 fatcat:edpqpqssm5dhxak5tfnbzkfn2u