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Dramatic Elevations of Interleukin-6 and Acute-Phase Reactants in Athletes Participating in the Ultradistance Foot Race Spartathlon: Severe Systemic Inflammation and Lipid and Lipoprotein Changes in Protracted Exercise

Alexandra Margeli, Katerina Skenderi, Maria Tsironi, Eugenia Hantzi, Antonia-Leda Matalas, Christina Vrettou, Emmanuel Kanavakis, George Chrousos, Ioannis Papassotiriou
2005 Journal of Clinical Endocrinology and Metabolism  

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https://web.archive.org/web/20200315081256/https://watermark.silverchair.com/jcem3914.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAlowggJWBgkqhkiG9w0BBwagggJHMIICQwIBADCCAjwGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMRJl2h2x89g0rWbEJAgEQgIICDWzdodOn_CO8LwYfRQ3ieYuHzxU_ILt9CS1gb8JzMcVnTfE6atSjWTWkq7lxaQzgE8VEfPPHpL4JdFWnZFqkv7aDsjWj-ErR_DJpMsxM8YBMIXLxK1H4pwhpIu_z96SlXpFy9Gam3Rft85xuBbzYl3o89gdBffXN2EqYDlS4OEpscgCWwqCYrOyisw0B90qKGFltGo7GDod9EH6ZwTmcTLoqDFoYfooABJIFtJIEd4d76e_MPav237J0eVWbP1nrepuLbCqnWQuhEtqskq-Ulx5zNtsT5DrdWGJG1c82U7ohG-KuXl9F2pHfC5BMurY_eLDDVRjZIWogs1lYQA3tWt5uTUlP5eJy9FTxVoOH4uPNnPOePhtGYzMKJgrt3qLOrHRVg9icX_GmLATEn_jUM6Q2NVbGt6hm93eyxmd-6XMzmpvk1KIh4aQ5b34JUOXNMgn_8RiPAPJKkxUXPe8rYFLR4XQsPORNwAObsL_tK3ohupgBHmJDbWfUDRp15Lvt0JetKfkERZfwHmypWSvw_pkQYWpWf4oOmi5FTlv4e4CkxwPamCE6IQaG1JrrCTFc8CteSxKN59JE7lx2SHVxKt2xuLLpYRV3bxQY_HtSIZCexRkJb3BL3miViaWl6UqlHxIf44vlHvJHUxoTfTynkloymMIkqZa1_9h5GJEKmr8LUiGlxnDASoZMmQjR8g

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Context and Objective: Plasma IL-6, the serum inflammatory markers C-reactive protein (CRP) and serum amyloid A (SAA), and the tissue destruction marker-free plasma DNA, as well as the circulating lipid profile, were examined in athletes participating in the ultradistance foot race of the 246-km Spartathlon. Setting, Design, and Participants: This race consists of continuous, prolonged, brisk exercise. Blood samples were obtained from 15 male athletes, who finished the race in less than 36 h,
more » ... ken before, at the end of, and 48 h after the end of the race. Results: IL-6, CRP, SAA, and free plasma DNA levels markedly increased (by 8000-, 152-108-, and 10-fold, respectively) over the baseline at the end of the race. However, IL-6 levels returned to normal by 48 h, whereas CRP, SAA, and free plasma DNA remained elevated. The mean values of cholesterol, triglycerides, low-density lipoprotein, and apolipoprotein B decreased to a minimum value at the end of the race and remained low 48 h after the race. High-density lipoprotein levels, on the other hand, were mildly increased at the end of the race (P Ͻ 0.015) and decreased to normal 48 h after the race. Apolipoprotein AI levels decreased significantly during the time course of the exercise and remained low 48 h after the race (P Ͻ 0.001). Conclusions: These observations suggest that continuous, prolonged, moderate-intensity exercise is associated with markedly elevated IL-6 and acute-phase reactant concentrations, peripheral tissue damage, and significant changes in serum lipid levels. The biochemical changes observed during the Spartathlon amount to a potent systemic inflammatory response, which might explain severe cardiovascular events that occur during prolonged exercise in compromised individuals. (J Clin Endocrinol Metab 90: 3914 -3918, 2005)
doi:10.1210/jc.2004-2346 pmid:15855262 fatcat:bfctl7vrmvel5audh3a64fmia4
Citation

Alexandra Margeli, Katerina Skenderi, Maria Tsironi, Eugenia Hantzi, Antonia-Leda Matalas, Christina Vrettou, Emmanuel Kanavakis, George Chrousos, Ioannis Papassotiriou. "Dramatic Elevations of Interleukin-6 and Acute-Phase Reactants in Athletes Participating in the Ultradistance Foot Race Spartathlon: Severe Systemic Inflammation and Lipid and Lipoprotein Changes in Protracted Exercise." Journal of Clinical Endocrinology and Metabolism 90.7 (2005) 3914-3918