Saponins from the Pericarp of Albizia lebbeck (Benth) L. and Their Biological Screening on Laboratory Animals

Basma G. Eid, Nadia M. Sokkar
2021 Journal of Pharmaceutical Research International  
Aim: Albizia lebbeck L. is widely used to treat many diseases. Saponins are one of the major constituents that are found in the tissues of the tree. The purpose of this study was aimed at the phytochemical and biological investigation of the saponins of the pericarp. Methodology: 50% ethanol extract of the dried powdered pericarp of A. lebbeck was fractionated with different organic solvents and examinated for their oxidative stress radical, anticonvulsant and analgesic effects. The highly
more » ... ts. The highly potent fraction was subjected to chromatographic and spectroscopic analysis of its saponins. Results: The n-butanol fraction expressed the best results regarding the biological activities. Chromatographic and spectroscopic analysis of this fraction revealed the identification of three oleanane-type saponins. Conclusion: The present study constituted the first phytochemical analysis of the bioactive saponins content in the pericarp of A. lebbeck. Graphical Abstract
doi:10.9734/jpri/2021/v33i28b31553 fatcat:aop2por2fnb7hoimrxqrbzsvci