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In this paper, we describe our experience in designing a virtual environment-based (VE) telerehabilitation system, and the results of a clinical study of the first 11 subjects with stroke to use the system. Our telerehabilitation system allows a therapist to conduct interactive VE treatment sessions remotely with a patient who is located at home. The system, software architecture, and development experience are described. Results of the clinical study on subjects with stroke showed significantdoi:10.1109/tnsre.2007.891388 pmid:17436874 fatcat:5igodnygefcffdom74e2vkfc74