Indolent lymphoma: follicular lymphoma and the microenvironment--insights from the microscope

N. L. Harris
2014 Hematology ASH Education Program  
Follicular lymphomas (FLs) are neoplasms of germinal center (GC) B cells, which retain many of the morphologic, immunophenotypic, genetic, and functional features of normal GC B cells. Both normal GCs and neoplastic follicles of FL also contain non-neoplastic cells (microenvironment) that influence and are influenced by the GC and FL B cells and are likely important for tumor cell survival. Many insights into the nature of the GC/FL microenvironment have come from morphologic and
more » ... and immunophenotypic analysis, both before and after the discoveries from gene expression profiling. This chapter reviews what we have learned from the microscope and highlights the pitfalls involved in trying to enumerate cells in the microenvironment for clinical prognostication. Learning Objective • To perceive the strong interconnections revealed by microscopic observation between immune system and stromal cells in the microenvironment and neoplastic cells in the development and progression of FL
doi:10.1182/asheducation-2014.1.158 pmid:25696849 fatcat:tlekvbopvvalrbr5g2n5keu2yy