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Diastereoselective Synthesis of 3-Fluoro-2-substituted Piperidines and Pyrrolidines
2014
Heterocycles
Preserved Fulltext
A facile procedure for synthesis of trans-3-fluoro-2-substituted piperidines by utilizing electrophilic fluorination of cyclic enamines and Lewis acid mediated nucleophilic substitution has been developed. Also, optically active trans-2-allyl-3-fluorinated pyrrolidines have been prepared by utilizing nucleophilic fluorination of hydroxyl group of trans-hydroxy-L-proline and Lewis acid mediated diastereoselective allylation as key steps.
doi:10.3987/com-13-s(s)27
fatcat:oo3ugvdp7zhdtfsdrbayj4b6vq