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Matrix-type transdermal drug delivery system of fluoxetine was prepared by solvent evaporation technique. Several batches were prepared by using different proportion of ethylcellulose (EC) and polyvinylpyrrolidone K-30 (PVP) as a film former and dibutyl phthalate as a plasticizer. Eucalyptus oil and olive oil in three different concentrations i.e. 2, 5 and 10% were also employed as a natural enhancer to enhance the skin permeation of fluoxetine. All the prepared patches were subjected todoi:10.20530/ijibcs_9_31-38 fatcat:5nf37jwu3rfcjf73p7txacevgu