Heterocycles [f]-Fused onto Quinolones. Synthesis of Novel Dioxo-Nethylpyrano[ 2,3-f ]- and [3,2-f ]quinoline-10-carboxylic Acids

Almeqdad Y. Habashneh, Mustafa M. El-Abadelah, Mohammad S. Mubarak, Wolfgang Voelter
2013 Zeitschrift für Naturforschung. B, A journal of chemical sciences  
A model N-ethyl-1,10-dioxo-3-phenylpyrano[3,2- f ]quinoline-9-carboxylic acid (8) and the isomeric (2-substituted) pyrano[2,3- f ]quinoline-9-carboxylic acids (6 and 7) were prepared from the corresponding 6/7-aminochromen-4-ones via the Gould-Jacobs reaction. The new tricyclic heterocycles 6-8 exhibit moderate antibacterial activity (MIC=16 - 64 μgmL-1) against E. coli and S. aureus
doi:10.5560/znb.2013-3122 fatcat:qzvzler6szcynmigv6qymytkcy