A facile microwave assisted one pot synthesis of novel xanthene derivatives as potential anti-inflammatory and analgesic agents

Anupam G. Banerjee, Lata P. Kothapalli, Piyoosh A. Sharma, Asha B. Thomas, Rabindra K. Nanda, Sushant K. Shrivastava, Vivek V. Khatanglekar
2016 Arabian Journal of Chemistry  
Microwave assisted irradiation of resorcinol and substituted aryl aldehydes using sulfamic acid as catalyst afforded novel 9-aryl-9H-xanthene-3,6-diol derivatives (1a-f) in good yields. The newly synthesized compounds which were previously selected on the basis of PASS prediction were tested for anti-inflammatory activity using carrageenan-induced rat paw edema and analgesic activity using acetic acid induced writhing and formalin-induced paw edema in mice along with the estimation of gastric
more » ... cerogenicity index. Compounds 1e and 1f exhibited significant antiinflammatory and analgesic activities as compared to standard drug. The study also revealed that compounds (1a-f) showed minimum or no ulcerogenicity in mice as that of the standard drug.
doi:10.1016/j.arabjc.2011.06.001 fatcat:amnurpbobnfp3kfs25i544djsi