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Estrogenic Effects of Fluorotelomer Alcohols for Human Estrogen Receptor Isoforms α and β in Vitro
Biological and Pharmaceutical Bulletin
The present study demonstrates the estrogenic effects of fluorotelomer alcohols (FTOHs). In a yeast two-hybrid assay, treatment with 1H,1H,2H,2H-perfluorooctan-1-ol (6:2 FTOH), 1H,1H,2H,2H-perfluoro-decan-1-ol (8:2 FTOH) and 2,2,3,3,4,-4,5,5,6,6,7,7,8,8,9,9,10,10,10-nonadecafluoro-1-decanol (NFDH) showed a dose-dependent interaction between the human estrogen receptor (hER) isoforms hERa a or hERb b ligand-binding domain and coactivator TIF2, whereas there were no estrogenic effects ofdoi:10.1248/bpb.30.1358 pmid:17603182 fatcat:omjjypvmmzap7c2u3h63rropmy