Objective: Urolithiasis is a common problem of various centuries with high recurrence. The present review is an attempt to share traditionally used antiurolithiatic plants with their mechanism of action. Chemical principles from herbal sources have become much simpler and have contributed significantly to the development of new drugs from medicinal plants. Urolithiasis is a common disorder expected to occur in approximately 12% of the population, with a recurrence rate of 70-81% in males, and

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... -60% in females. It causes serious health problems such as severe pain, urinary tract obstruction and infection that adversely affect well-being of individuals. Treatment option includes like surgical, ureteroscopy, percutaneous nephrostolithotomy (PCNL), and open or laparoscopic stone removal which are costly and painful. Many synthetic drugs used like diuretics and narcotic analgesics are being used in treatment of kidney stone but overuse of synthetic drugs, which produce higher incidence of adverse drug effect, have forced humans to return to nature for safe remedies herbal treatment. Conclusion: The present review covered all the information about litholytic medicinal plants. The use of herbal remedies for prevention and cure of ailments is of increasing interest due to the superiority and efficiency of activity provided by natural constituents in herbs and undesirable effects of modern medicine. Evidences prove that natural therapy is more valuable than other available treatments, with lesser side effects, economic nature, no risk of long term fertility and reoccurrence. We covered all potent indigenous herbs which are used in treatment of urolithiasis disease. This review will give the opportunities for the future research and for the development of new antiurolithiatic compounds.