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CDX2 is essential for cell proliferation and polarity in porcine blastocysts
The role of CDX2 in trophectoderm (TE) cells has been extensively studied, yet the results are contradictory and species specific. Here, CDX2 expression and function were explored in early porcine embryos. Notably, siRNA-mediated gene knockdown and lentivirusmediated TE-specific gene regulation demonstrated that CDX2 is essential for the maintenance of blastocyst integrity by regulating the BMP4-mediated blastocyst niche and classic protein kinase C (PKC)mediated TE polarity in mammaliandoi:10.1242/dev.141085 pmid:28219949 fatcat:aw4hvidlifhcvbllsdlzsu7ugq