Angiotensin Converting Enzyme Inhibitors Attenuated the Expression of G-Protein Coupled Receptor Kinases in Heart Failure Patients

Naotsugu Oyama, Kazushi Urasawa, Satoshi Kaneta, Hidetsugu Sakai, Takahiko Saito, Chika Takagi, Ichiro Yoshida, Akira Kitabatake, Hiroyuki Tsutsui
2006 Circulation Journal  
Lymphocyte GRK mRNA expression was measured by quantitative RT-PCR in 15 congestive heart failure patients: 5 in NYHA class-II treated with ACEI (IIA), 5 in NYHA class-II without ACEI (IIC) and 5 in NYHA class-III treated with ACEI (IIIA). GRK2 and GRK5 mRNA of IIIA were significantly higher than those in IIA. GRK mRNA expression level in IIA were significantly lower than those of IIC. These results suggest that the expression level of lymphocyte GRK may reflect the severity of CHF, and that
more » ... of CHF, and that ACEI treatment could reduce the level of GRK in CHF patients.
doi:10.1253/circj.70.362 pmid:16501306 fatcat:fcwhoj6fnbg3zgaumsyyuvzyti