3D printing of porous polymeric materials for stationary phases of chromatography columns [article]

Roya Rezanavaz, University Of Canterbury
The work described in this thesis focused on the creation of 3D printed chromatography columns using high internal phase emulsion polymer (polyHIPE) materials. The first step was to prepare and optimize a porous, polymeric stationary phase for chromatography. An approach used throughout the work was based on a special type of emulsion polymerization, the HIPE, which results in a highly porous, interconnected structure, in which the pore size and pore size distribution can be tightly controlled.
more » ... tightly controlled. Glycidyl methacrylate (GMA) is a reactive monomer that is frequently used for the preparation of functional polymers. The possibility of preparation of materials with a high level of porosity (up to 90%), pore size tuning and the availability of an epoxy reactive group for further chemical modification to include adsorptive ligands make GMA-based polyHIPEs good candidates for chromatographic applications. Photo polymerization of GMA-based HIPE was achieved with a UV lamp operating at a 300-400 nm wavelength. Scanning electron microscopy and the Brunauer–Emmett–Teller method were used to analyze the size and distribution of porosity as well as the surface area of the materials. The polyHIPE materials reported to date have typically been weak and brittle, with a chalky consistency that crushes and readily breaks down under applied stress. The mechanical properties of the prepared porous polyHIPE materials were therefore improved using crosslinkers or co-crosslinkers of high molecular weights (average MW 286 and 550 g mol-1). The Young's modulus of GMA-based polyHIPEs containing 40% PEGDMA increased by 50% and the crush strength by 400% when compared with traditional GMA/Ethylene glycol dimethylacrylate polyHIPEs. Subsequent morphological studies showed that the mechanically improved foams possessed the characteristic interconnected pore structure and properties of typical polyHIPEs, meaning that mechanical strength was improved without a loss of the desired high internal porosity. For the first time, 3D-printed chromatograph [...]
doi:10.26021/1788 fatcat:pe6ntbkk6vax3e65bbiytiuape