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Development and validation of combined dosage form of Torsemide and Spironolactone in Ultra-violet spectroscopy by simultaneous equation method

V.C. Rajeshwari, S. Ravichandran
2018 International Journal of ChemTech Research  

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A simple, accurate and precise spectrophotometric method has been developed for simultaneous estimation of Torsemide (TOR) and Spironolactone (SPI) in combined dosage form. Simultaneous equation method (Vierordt's method) was employed for determination of TOR and SPI from combined dosage forms. In this method, the absorbance was measured at 288 nm for TOR and SPI from combined dosage forms. In range of 1-5μg/ml and 5-25μg/ml for TOR and SPI respectively. Recovery studies confirmed the accuracy
more » ... f proposed method and results were validated as per ICH guidelines. The method can be used for routine quality control of pharmaceutical formulation containing Torsemide and Spironolactone.
doi:10.20902/ijctr.2018.110908 fatcat:2udyh3xsvzb23jqg6v6bhm2kyi
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V.C. Rajeshwari, S. Ravichandran. "Development and validation of combined dosage form of Torsemide and Spironolactone in Ultra-violet spectroscopy by simultaneous equation method." International Journal of ChemTech Research 11.9 (2018) 53-57