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We study self-duality for interacting particle systems, where the particles move as continuous time random walkers having either exclusion interaction or inclusion interaction. We show that orthogonal self-dualities arise from unitary symmetries of the Markov generator. For these symmetries we provide two equivalent expressions that are related by the Baker-Campbell-Hausdorff formula. The first expression is the exponential of an anti Hermitian operator and thus is unitary by inspection; thedoi:10.3842/sigma.2019.053 fatcat:6bjkfziyvrfd7dgtxzs245ajjm