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SYNTHESIS AND CHARACTERIZATION OF A NEW STARCH ESTER WITH N-[(N'-TIAZOLYL)-p'-(BENZENESULPHONE)] AMIDE OF N-(o-NITROBENZOYL)-D,L-ASPARAGIC ACID

Mihaela Holban, Valeriu Sunel, Marcel Popa, Catalina Lionte, " Alexandru
2011 CELLULOSE CHEMISTRY AND TECHNOLOGY Cellulose Chem. Technol   unpublished

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The paper studies the dicyclohexylcarbodiimide-activated coupling reaction through ester-type covalent bonds of a sulfonamide derived from N-(m-nitrobenzoyl)-L-asparagic acid on starch. The amount of sulfonamide chemically-bonded to the support is dependent on the reaction parameters, the maximum coupling efficiency being attained at the highest values of the reaction parameters (DCC/sulfonamide molar ratio, sulfonamide/starch molar ratio and reaction time). The kinetics of drug release from
more » ... conjugates is studied under alkaline hydrolysis conditions. The conjugates present low toxicity and medium level antimicrobial activity against E. coli and S. aureus strains.
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Mihaela Holban, Valeriu Sunel, Marcel Popa, Catalina Lionte, " Alexandru. "SYNTHESIS AND CHARACTERIZATION OF A NEW STARCH ESTER WITH N-[(N'-TIAZOLYL)-p'-(BENZENESULPHONE)] AMIDE OF N-(o-NITROBENZOYL)-D,L-ASPARAGIC ACID." CELLULOSE CHEMISTRY AND TECHNOLOGY Cellulose Chem. Technol 45.3-4 (2011)