In vitro fertilization requires the harvesting of mature oocyte from the ovaries of infertile women under direct sonography, a process for which some form of anesthesia and analgesia is still required. Objectives: Evaluation the effect of rectal paracetamol on intraoperative sedation using bispectral index monitoring and postoperative pain using numeric rating scale in these group of patients. Pregnancy and implantation rates were also recorded. Material/patients and methods: Eighty ASA classes

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... I or II women who were scheduled for oocyte retrieval were allocated into two equal groups and received rectal paracetmol or placebo one hour before surgery according to the allocations. Patients anesthetized with fentanyl and propofol and anesthesia was maintained with propofol infusion to achieve Bispectral Index value between45-65. Demographic data, Intraoperative propofol and fentanyl consumption, postoperative pain score and pregnancy and implantation rate were also recorded and compared between the two groups. Results: Demographic data were not statistically different between the study groups. Intraoperative propofol consumption was 67.4 ± 38.1 µg/kg/min in paracetamol and 87.0 ± 47.9 µg/kg/min in placebo group (P=0.04). No patient required additional fentanyl during the operation (P=0.06).Thirty two patients in paracetamol group and fourteen patients in placebo group had numeric rating scale ≤ 3 that was statistically significant (P<0.001). There was no difference in pregnancy and implantation rate between the study groups. Conclusion: preoperative rectal paracetamol reduced propofol consumption and postoperative pain in infertile women undergoing oocyte retrieval for invitro fertilization treatment. Pregnancy and implantation rates did not affected in this group of patients.