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To determine the possible neuroprotective effect of pramipexole (PPX) against glutamate-induced neurotoxicity, we analyzed the neuroprotective utility of PPX on a postnatal organotypic culture model of rat spinal motor neuron degeneration. Methods and Results : Treatment with 10 -5 M of glutamate resulted in a motor neuron loss and decreased activity of choline acetyltransferase (ChAT). Cotreatment of 10 -5 M of glutamate and PPX revealed a protective effect against motor neuron death anddoi:10.4021/jnr61w fatcat:zowhcb7jzvbqtmvnh5evlwzldq