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This paper proposes using estimation of distribution algorithms for unsupervised learning of Bayesian networks, directly as well as within the framework of the Bayesian structural EM algorithm. Both approaches are empirically evaluated in synthetic and real data. Specifically, the evaluation in real data consists in the application of this paper's proposals to gene expression data clustering, i.e., the identification of clusters of genes with similar expression profiles across samples, for thedoi:10.1142/s0218488504002588 fatcat:dycbnv3sfnbtrihd4khzutorcm