UNSUPERVISED LEARNING OF BAYESIAN NETWORKS VIA ESTIMATION OF DISTRIBUTION ALGORITHMS: AN APPLICATION TO GENE EXPRESSION DATA CLUSTERING

J. M. PEÑA, J. A. LOZANO, P. LARRAÑAGA
2004 International Journal of Uncertainty Fuzziness and Knowledge-Based Systems  
This paper proposes using estimation of distribution algorithms for unsupervised learning of Bayesian networks, directly as well as within the framework of the Bayesian structural EM algorithm. Both approaches are empirically evaluated in synthetic and real data. Specifically, the evaluation in real data consists in the application of this paper's proposals to gene expression data clustering, i.e., the identification of clusters of genes with similar expression profiles across samples, for the
more » ... s samples, for the leukemia database. The validation of the clusters of genes that are identified suggests that these may be biologically meaningful.
doi:10.1142/s0218488504002588 fatcat:dycbnv3sfnbtrihd4khzutorcm