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Preclinical as well as clinical studies in traumatic brain injury (TBI) have established the likely association of secondary injury and outcome in adults in children following severe injury. Similarly, there is growing evidence in experimental laboratory studies that moderate hypothermia has a beneficial effect on outcome, though the exact mechanisms remain to be absolutely defined. The Pediatric TBI Guidelines provided the knowledge and background for standard management of children followingdoi:10.1089/neu.2008.0571 pmid:19271965 pmcid:PMC2744377 fatcat:e75t3zk4abbdpctzqq75wu52z4