Power of Lifestyle Medicine: Improving Oxidative Stress Profile of High Risk Lifestyle Disease Patients in Rural Germany

Sarah Husain, Heike Englert
2021 Current Developments in Nutrition  
Objectives Lifestyle diseases share risk factors similar to prolonged exposure to three modifiable lifestyle behaviours—smoking, unhealthy diet, and physical inactivity—and result in the development of chronic diseases. However, Inflammation and oxidative stress contribute to the pathophysiology of gamut of chronic diseases. Therefore, we examined the links between oxidative stress parameters and chronic diseases through a lifestyle medicine concept. This study evaluates if lifestyle medicine
more » ... ncept is suitable for improving the oxidative stress parameters in the participants after 10 weeks of intervention. Methods The participants were recruited from the public in two separate small towns in rural North-West Germany. Lifestyle medicine concept focuses on 4 very important pillars of overall health; nutrition, physical activity, stress and social health. The intervention group (n = 103) took part in a 10-week intensive lifestyle intervention programme followed which consists of 15 biweekly seminars, workshops (cooking, physical activity, integration, stress management) shopping tours followed bi-monthly seminars for our Alumni's. Our control group (n = 57) was not given any treatment. Plasma Glutathione (GSH), Superoxide dismutase (SOD), Lipid peroxidation (LPO), total phenol content (TPC) and catalyse enzyme (CAT) along with anthropometric data, lipid profile, Hba1c, Fasting glucose, food logs were collected at baseline, at 10 weeks, 6-month and 12-month intervals. Results Post lifestyle intervention (after 10 weeks) values revealed significant reduction of systolic blood pressure (P < 0.0001) and diastolic blood pressure (P < 0.0001) besides all fasting lipids decreased. Moreover, there was significant increase in the GSH (P < 0.0001), CAT (P < 0.0001), TPC (P < 0.0001) and SOD (P < 0.0001), whereas significant decrease in the MDA (P < 0.0001) was recorded. Conclusions Preliminary data from our lifestyle intervention study suggest that a well-planned lifestyle medicine concept is able to improve oxidative stress parameters in high risk lifestyle disease participants in rural German. Funding Sources www.bmbf.de
doi:10.1093/cdn/nzab033_023 fatcat:sojdi6ayazavfdhe2e7gkdiqby