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The ␣ and ␤ subunits of ␣/␤ heterodimeric integrins function together to bind ligands in the extracellular region and transduce signals across cellular membranes. A possible function for the transmembrane regions in integrin signaling has been proposed from structural and computational data. We have analyzed the capacity of the integrin ␣ 2 , ␣ IIb , ␣ 4 , ␤ 1 , ␤ 3 , and ␤ 7 transmembrane domains to form homodimers and/or heterodimers. Our data suggest that the integrin transmembrane helicesdoi:10.1074/jbc.m312749200 pmid:14681217 fatcat:sesrkkzsbrakdh6nm2pp72ceny