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There is still an unmet need of mapping the potential impairment of cerebrovascular reactivity (CVR) in episodic migraineurs in the interictal state. We mapped CVR of 6 episodic migraineurs and 5 headache-free controls (HC) with blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) under carbon dioxide (CO ) challenge of 30-second epochs with elevated end-tidal partial pressure of CO (P CO ) by 4-8mmHg. Three migraineurs have migraine without aura (MOA) and thedoi:10.1101/859843 fatcat:gp5rcdhl2zgxzowfwbcee6oecq