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Resolving Behavioral Output via Chemogenetic Designer Receptors Exclusively Activated by Designer Drugs
2016
Journal of Neuroscience
Designer receptors exclusively activated by designer drugs (DREADDs) have proven to be highly effective neuromodulatory tools for the investigation of neural circuits underlying behavioral outputs. They exhibit a number of advantages: they rely on cell-specific manipulations through canonical intracellular signaling pathways, they are easy and cost-effective to implement in a laboratory setting, and they are easily scalable for single-region or full-brain manipulations. On the other hand,
doi:10.1523/jneurosci.1333-16.2016
pmid:27605603
pmcid:PMC5013180
fatcat:vn5zwbbmenanbpyqv3es6ae73y