Internet Archive Scholar

Extended erythrocyte and reticulocyte parameters in the diagnosis of iron deficiency in hemodialysis patients

Mohammed Nazim Bennaoum, Department of Hemobiology EHU ", Affaf Adda, Mohamed Chekkal, Fatima Seghier, 1er Novembre 1954", Oran, Algeria, University of Oran 1 Ahmed Ben Bella Faculty of Medicine, Department of Hemobiology EHU "1er Novembre 1954" Oran, Algeria, University of Oran 1 Ahmed Ben Bella Faculty of Medicine, Department of Hemobiology EHU "1er Novembre 1954" Oran, Algeria, University of Oran 1 Ahmed Ben Bella Faculty of Medicine (+2 others)
2020 Chinese Journal of Medical Research  

Preserved Fulltext

fulltext thumbnail
Web Archive Capture PDF (454.1 kB)
https://web.archive.org/web/20210719010332/https://www.cjmronline.com/CJMR_202034_05.pdf

A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2021; you can also visit the original URL. The file type is application/pdf.

Objective: Iron deficiency (ID) is a frequent complication in end stage renal insufficiency. These patients have to be diagnosed and treated to reduce the prevalence of anemia. Functional iron deficiency (FID) is a situation that can disrupt biochemical iron tests and mask an eventual association with ID. In this study, we tried to prove the ability of extended parameters of red cells and reticulocytes to diagnose ID without being influenced by FID. Design and methods: 164 chronic hemodialysis
more » ... atients (CHP) in end stage renal disease were enrolled. Research parameters of red cells and reticulocytes determined on ADVIA 2120i were studied in the diagnosis of ID associated or not with chronic inflammation. Results: Parameters such as corpuscular hemoglobin of mature red cells (CHm), corpuscular hemoglobin of reticulocytes (CHr), cellular concentration of hemoglobin in mature red cells (CHCMm), cellular concentration of hemoglobin in reticulocytes (CHCMr) and percentage of microcytic and hypochromic red cells (HYMI) showed a high sensitivity to diagnose ID. However, the distinction of combined iron deficiency (CID) from other entities was not possible with all parameters. In chronic inflammatory states, the decrease of CHm, CHCMm and CHCMr with the rise of percentage hypochromic mature red cells (HYPOm) and reticulocytes (HYPOr) is in favor of CID. So, determination of inflammatory state is needed to complete research parameters of blood count in CHP. Conclusion: Extended erythrocyte and reticulocyte parameters can be useful to check iron status in CHP.
doi:10.37515/cjmr.091x.3405 fatcat:l3hib4rhnncuda6uwgp72s7d2y
Citation

Mohammed Nazim Bennaoum, Department of Hemobiology EHU ", Affaf Adda, Mohamed Chekkal, Fatima Seghier, 1er Novembre 1954", Oran, Algeria, University of Oran 1 Ahmed Ben Bella Faculty of Medicine, Department of Hemobiology EHU "1er Novembre 1954" Oran, Algeria, University of Oran 1 Ahmed Ben Bella Faculty of Medicine, Department of Hemobiology EHU "1er Novembre 1954" Oran, Algeria, University of Oran 1 Ahmed Ben Bella Faculty of Medicine, University of Oran 1 Ahmed Ben Bella Faculty of Medicine, Department of Hemobiology CHU Oran, Algeria. "Extended erythrocyte and reticulocyte parameters in the diagnosis of iron deficiency in hemodialysis patients." Chinese Journal of Medical Research 3.4 (2020) 109-113